Bacteriophage adhering to mucus provide a non–host-derived immunity

By J. Barr, Rita Auro, Mike Furlan, Katrine L. Whiteson, M. Erb, J. Pogliano, Aleksandr Stotland, R. Wolkowicz, A. S. Cutting, K. Doran and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2013

883 citations recorded by the source corpus.

Subfields: Ecology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/36594542e59cc05905e31b40427e2203afea04e6

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Citations in the corpus

The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Recently it has been shown that phages on the mucosal surface of metazoans provide defense against bacterial pathogens (Barra et al. 2013).”
Disease-specific Alterations in the Enteric Virome in Inflammatory Bowel Disease (2015, background): “Bacteriophages may also play a direct role in intestinal physiology or change the bacterial microbiome through predator-prey relationships (Barr et al., 2013; Duerkop et al., 2012; Reyes et al., 2013; Willner et al., 2009, 2012).”
Mechanisms and consequences of intestinal dysbiosis (2017, background): “Adhesion to intestinal glycoproteins increases the bacteriophage density in the mucus layer, which acts as a protective barrier for the host by killing mucus-penetrating bacteria [117].”
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study (2017, background): “In healthy individuals, the gut virome is highly stable over time [23, 47, 69], with some phage populations hypothesized to provide a non-hostderived protective barrier to invading bacterial pathogens [70, 71].”
VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences (2020, background): “In human systems, viruses have been implicated in contributing to dysbiosis that can lead to various diseases, such as inflammatory bowel diseases, or even have a symbiotic role with the immune system [11 – 13].”
Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes (2015, background): “Moreover, the microbiota itself is now recognized as essential in the training and function of the holobiont immune system [47], including the remarkable possibility that mucusassociated bacteriophages operate as part of the adaptive and innate antimicrobial immune system [174].”