High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.
By S. Walenta, Michael Wetterling, M. Lehrke, G. Schwickert, K. Sundfør, E. Rofstad, W. Mueller‐Klieser. Cancer Research, 2000
847 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/f3cdaabfa809db01fe01977a4e5667bab1bc57ca
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Citations in the corpus
- Why do cancers have high aerobic glycolysis? (2004, unknown): “gov/cancertopics/types/head-and-neck">head and neck cancers”
- Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles (2009, background): “Several metabolites in tumor tissues, such as lactate, which is derived from tumor exposed to hypoxia, were altered both with and without metastasis (Hirayama et al. 2009; Walenta et al. 2000).”
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, methodology): “It has been shown that high concentrations of lactate in biopsies of cervical, lung, head and neck, colorectal and breast cancers are associated with an increased risk for developing metastasis, and such levels of lactate indicate a bad prognosis for survival in cancer patients (30, 31, 35, 167) (Ta”
- Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “Elevated rates of 18F-FDG uptake are strongly negatively correlated to patient outcome in many cancers (51,61), as are elevated lactate levels (62,63).”
- Tumor glycolysis as a target for cancer therapy: progress and prospects (2013, background): “A higher lactate level significantly correlates with tumor recurrence and the metastatic potential of tumors resulting in poor patient outcomes [66].”
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. (2016, background): “In primary human tumors, high levels of lactate correlate with incidence of distant metastases (Walenta et al., 2000), and the level of LDHA correlates with the size and clinical stage of renal cell carcinomas and gastric cancer (Girgis et al., 2014; Sun et al., 2014).”