Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.

By M. Briel, M. Meade, A. Mercat, R. Brower, D. Talmor, Stephen D. Walter, Arthur S Slutsky, E. Pullenayegum, Qi Zhou, D. A. Cook and 6 more. Journal of the American Medical Association (JAMA), 2010

1,448 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/f36be3d722b6125d9771e87b249cc78dafeee7d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Critical Care and Intensive Care Medicine

1. W. Organization
2. Jean-Louis Vincent
3. Mitchell M. Levy
4. Julian P. T. Higgins

In Epidemiology

1. Jean-Louis Vincent
2. Mitchell M. Levy
3. A. Rhodes
4. W. Organization
5. Laura Evans
6. Janice L. Zimmerman
7. R. Dellinger
8. Julian P. T. Higgins

In Pulmonary and Respiratory Medicine

1. Arthur S Slutsky
2. W. Organization
3. Jean-Louis Vincent
4. A. Anzueto

Citations in the corpus

• Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial (2017, neutral): “Time since onset of ARDS, median (IQR), h 15 (7-34) 16 (7-30)”
• Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. (2016, background): “Duration of invasive mechanical ventilation, median (IQR), d 8 (4-16)”
• GRADE guidelines: 7. Rating the quality of evidence--inconsistency. (2011, background): “low positive end-expiratory pressures (PEEPs) in three randomized trials that enrolled 2,299 adult patients with severe acute lung injury requiring mechanical ventilation [17].”
• Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) (2020, neutral): “75), at the expense of a possible increase in the risk of pneumothorax (106).”
• Association of hospital-level volume of extracorporeal membrane oxygenation cases and mortality. Analysis of the extracorporeal life support organization registry. (2015, methodology): “Second, programs with best practice protocols may now have lower within-institution populations eligible for ECMO because they are able to avert ECMO by applying evidencebased approaches, such as inhaled nitric oxide (40), low tidal volume ventilation (41), open lung ventilation (42), and ventricula”
• Evolution of mortality over time in patients receiving mechanical ventilation. (2013, background): “However, in patients with moderate to severe ARDS (39), higher levels of PEEP were associated with a significant 4% absolute mortality reduction (40).”
• The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation (2017, result): “Clinical trials concerning the setting of PEEP have been less conclusive [39–41], but meta-analyses suggest that “higher PEEP” might benefit patients with moderate/severe ARDS [42].”
• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “A patient-level meta-analysis showed no benefit in all patients with ARDS; however, patients with moderate or severe ARDS (Pao 2 /Fio 2 ≤ 200 mm Hg) had decreased mortality with the use of higher PEEP, whereas those with mild ARDS did not (367).”