The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

By M. Guzman, R. M. Rossi, Lilliana Karnischky, Xiaojie Li, Derick R. Peterson, D. Howard, C. Jordan. Blood, 2005

717 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f3289b02ce156f5245e19811e26799bc9b0f3942

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Guido Kroemer
2. L. Galluzzi
3. Simone Fulda
4. G. Barrera

In Molecular Biology

1. L. Galluzzi
2. Guido Kroemer
3. Simone Fulda
4. G. Barrera
5. Douglas R. Green
6. Beth Levine
7. Oliver Kepp
8. Thomas G. Cotter

Citations in the corpus

• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “Guzman et al. (2005) showed that parthenolide induces apoptosis of LSCs in acute myelogenous leukemia (AML) and blast crisis chronic myelogenous leukemia (CML) by increasing ROS levels [233].”
• Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (2007, background): “Because LS cells exclusively initiate AML in vivo and are resistant to conventional chemotherapy, novel therapeutic strategies specifically targeting LS cells are needed to prevent disease relapse in human AM”
• Targeting mitochondria for cancer therapy (2010, background): “Parthenolide cytotoxicity reportedly involves ROS overproduction, nuclear factor-κB inhibition as well as the activation of p53 and pro-apoptotic BCL-2 family member”