Vitamin E and donepezil for the treatment of mild cognitive impairment.

By Ronald C. Petersen, Ronald G. Thomas, M. Grundman, David A. Bennett, R. Doody, S. Ferris, D. Galasko, Shelia Jin, J. Kaye, A. Levey and 4 more. New England Journal of Medicine, 2005

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Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies (2009, background): “(2005) (37) 3 RCT in specialist centres Amnestic mild cognitive impairment of a degenerative nature (insidious onset and gradual progression), seven impaired memory, a Logical Memory delayed-recall score approximately 1.”
Therapeutics of Alzheimer's disease: Past, present and future. (2014, background): “Combination of vitamin E with donepezil did not provide additional benefit in patients with AD or mild cognitive impairment (Petersen et al., 2005).”
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. (2008, background): “2 points associated with the use of donepezil at 18 months.(4) Importantly, the ADASCog results remained largely unchanged when only people meeting criteria for the diagnosis of mild cognitive impairment were included in the analyses, suggesting that our sampling strategy cannot explain our findings”