Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies

By A. Mitchell, M. Shiri-Feshki. Acta Psychiatrica Scandinavica, 2009

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. (2012, methodology): “Since MCI cases, especially amnestic cases, have a higher than normal risk of developing AD (93), our data suggest that brain insulin resistance may begin at a predementia stage of AD.”
2016 Alzheimer's disease facts and figures (2016, positive): “MCI is a condition in which an individual has mild but measurable changes in thinking abilities that are noticeable to the person affected and to family members and friends, but do not affect the individual’s ability to carry out everyday activities.”
Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta‐analysis (2014, methodology): “6) in relation to progression of MCI to dementia (29).”
Brain imaging in Alzheimer disease. (2012, methodology): “2006) and a recent meta-analysis concluded that most people with MCI will not progress to dementia even after 10 years of follow-up (Mitchell and Shiri-Feshki 2009).”
Imaging based enrichment criteria using deep learning algorithms for efficient clinical trials in MCI (2015, background): “dementia among MCI due to AD is 3%–20% across several studies [7], where the relatively lower rates are observed in population-based cohorts and higher rates in clinical settings.”