Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring

By Limin Shi, S. Fatemi, R. Sidwell, P. Patterson. Journal of Neuroscience, 2003

1,019 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Epidemiology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/f31c408bfb0418854d692d79a252ad974d4c26bf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. P. Boksa
2. Cameron J. Jones
3. Djg Watson
4. K. Fone
5. Tim Folsom
6. S. Fatemi
7. P. Patterson

In Epidemiology

1. P. Boksa
2. P. Patterson
3. Cameron J. Jones
4. Djg Watson
5. K. Fone
6. Tim Folsom
7. S. Fatemi

In Social Psychology

1. P. Boksa
2. P. Patterson
3. Tim Folsom
4. S. Fatemi
5. E. Hsiao

Citations in the corpus

• Animal models of schizophrenia (2011, background): “Similar studies with poly I : C administration to pregnant mice showed that this produced deficits in PPI (Shi et al., 2003), and enhanced methamphetamine-induced locomotion and reduced novel object discrimination, the latter being reversed by 14 days pretreatment with clozapine, but not…”
• Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism (2012, background): “S1) that we have seen in single-injected mothers and influenza-infected mothers (Shi et al., 2003; Smith et al., 2007; Hsiao and Patterson, 2011).”
• Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders (2010, background): “Shi et al. (2003) concluded from an animal study that the offspring of influenza-infected mice display abnormal behavioral responses; i.e.”
• Is the 1918 Influenza Pandemic Over? Long‐Term Effects of In Utero Influenza Exposure in the Post‐1940 U.S. Population (2006, background): “…analysis of preserved serum samples drawn from pregnant women between 1959 and 1966 in Oakland, California, where influenza antibodies predicted schizophrenia in adult offspring (Brown et al. 2004), as well as controlled experiments with a human influenza strain adapted to mice (Shi et al. 2003).”
• Early-Life Programming of Later-Life Brain and Behavior: A Critical Role for the Immune System (2009, background): “Similarly, infl uenza administered to pregnant mice increases cytokine levels in placental tissue and amniotic fl uid, and results in abnormal development of the offspring (Shi et al., 2003).”
• The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, positive): “The response by offspring of exposed mice to both antipsychotics shows that our animal model has predictive validity for positive symptoms of schizophrenia.(60) Our laboratory has previously shown that infection of BALB/c mice at E9 has deleterious effects on brain morphology(67,70) (figure 1).”
• Serologic evidence of prenatal influenza in the etiology of schizophrenia. (2004, neutral): “Trimester 1 20 5 (25) 38 4 (11) 2 48 7 (15) 82 11 (13) 3 63 12 (19) 121 21 (17) First half of pregnancy 43 9 (21) 75 7 (9) Second half of pregnancy 64 13 (20) 125 30 (24)”
• Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6 (2007, methodology): “…into pregnant rodents produces behavioral and histological abnormalities in the adult offspring similar to those seen in the offspring of infected mothers (Shi et al., 2003; Zuckerman et al., 2003; Fortier et al., 2004a; Zuckerman and Weiner, 2005; Meyer et al., 2006; Ozawa et al., 2006).”
• Effects of prenatal infection on brain development and behavior: a review of findings from animal models. (2010, positive): “…chlorpromazine or clozapine just prior to behavioral testing were shown to reverse PPI deficits in mice pre- natally exposed to influenza (Shi et al., 2003) and to reverse changes in PPI (Borrell et al., 2002; Romero et al., 2007), latent inhibition and reversal learning (Zuckerman et…”
• The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology (2006, background): “This represents a robust effect of mid- but not late-pregnancy immune activation (Shi et al., 2003; Meyer et al., 2005).”