The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology

By U. Meyer, M. Nyffeler, A. Engler, A. Urwyler, Manfred Schedlowski, Irene Knuesel, B. Yee, J. Feldon,. Journal of Neuroscience, 2006

789 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/0bb0400617ca3e2e077a4330afe899b9c1b9b579

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. P. Boksa
2. Cameron J. Jones
3. Djg Watson
4. K. Fone
5. P. Patterson
6. Eran Elinav

In Immunology

1. P. Boksa
2. Cameron J. Jones
3. Djg Watson
4. K. Fone
5. M. Schwartz
6. P. Patterson
7. Eran Elinav
8. M. Sieweke

In Pediatrics, Perinatology and Child Health

1. P. Boksa
2. Tessa J. Roseboom
3. B. V. D. Van den Bergh
4. M. Weinstock

Citations in the corpus

• Animal models of schizophrenia (2011, methodology): “…compared the effect of prenatal challenge with a variety of immune-activating agents on the development of altered PPI in the offspring, and showed that maternal infection during GD15-19 produced effects dependent on the agent used (Fortier et al., 2007; Boksa, 2010; see also Meyer et al., 2006a).”
• Effects of prenatal infection on brain development and behavior: a review of findings from animal models. (2010, positive): “Administration of LPS or poly IC to the rodent during pregnancy can clearly increase maternal levels of serum cytokines, including IL-1b, IL-6 and TNF-a, and produce fever (see e.g. Fortier et al., 2004a; Gayle et al., 2004; Ashdown et al., 2006, 2007; Meyer et al., 2006a).”
• Microglia regulate the number of neural precursor cells in the developing cerebral cortex (2013, background): “1) may provide a mechanism to help explain why the timing of maternal immune activation during gestation has a differential impact on neuropathology and behavior (Meyer et al., 2006).”
• Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism (2012, background): “The inflammatory cytokine response in pregnant mice induced by an acute systemic challenge of poly(I:C) is time-limited, and the time of maternal immune challenge influences the pattern of behavioral abnormalities in the offspring (Meyer et al., 2006).”
• Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. (2017, background): “Reduced HRV is associated with dysregulation of various allostatic systems, including glucose regulation, HPA axis function, and inflammatory processes (Thayer and Sternberg, 2006), all of which may program fetal brain development (Leff-Gelman et al., 2016; Matthews and Phillips, 2010; Meyer et al.,”
• Microglia development follows a stepwise program to regulate brain homeostasis (2016, background): “The precise effects of perturbations on development are highly dependent on the timing of infection, suggesting interference with specific processes (34, 35).”