Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
By Claudiu T. Supuran. Nature reviews. Drug discovery, 2008
3,021 citations recorded by the source corpus.
Subfields: Molecular Biology, Pharmacology, Physical and Theoretical Chemistry
View Paper: https://www.semanticscholar.org/paper/f301b27934489fac1194e338f8936fbb54278ac0
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In Molecular Biology
- Claudiu T. Supuran
- J. Pouysségur
- J. Chiche
- M. Brahimi-Horn
- N. Mazure
- Christopher M. Overall
- A. Minchinton
- S. Dedhar
In Pharmacology
In Physical and Theoretical Chemistry
Citations in the corpus
- How many carbonic anhydrase inhibition mechanisms exist? (2016, background): “Indeed, a wide range of primary sulfamates and sulfamides were shown to possess potent such properties, in all aspects similar to the isosteric sulfonamides, considering the binding to the enzyme, mechanism of action, pharmacology, etc.(1,5,6,167).”
- Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. (2009, background): “Such inhibitors are being actively investigated at the molecular and cellular levels (23, 24) and may hold promise as effective anticancer treatments.”
- Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. (2011, methodology): “First, we investigated the ability of the metastatic and non-metastatic cells to bind to a previously described, highly selective sulfonamide-based inhibitor of CAIX (CAI17) with a Ki in vitro of 24 nM (8).”
- Combination therapy in combating cancer (2017, background): “CAIs range from having nonisoform-specific activity to isoform-specific activity, and thus, whether to use pan-CAI treatment verses isoformspecific CAI depends on the type of therapy required [78, 80].”
- Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “Such inhibitors are being actively investigated at the molecular and cellular levels and may hold promise as effective anticancer treatments [143, 199].”