Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

By Derek C. Radisky, D. Levy, L. Littlepage, Hong Liu, C. Nelson, J. Fata, D. Leake, Elizabeth L. Godden, Donna Albertson, M. Nieto and 2 more. Nature, 2005

1,325 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Rheumatology

View Paper: https://www.semanticscholar.org/paper/f2ff024329ca70c5ab81c9288b5fac86e5dd8366

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Stephanie Alexander
2. Peter Friedl
3. Zena Werb
4. V. Plaks
5. K. Kessenbrock
6. M. Nieto
7. Mina J. Bissell
8. A. Dinkova-Kostova

In Immunology and Allergy

1. Stephanie Alexander
2. Kenneth M. Yamada
3. Zena Werb
4. Peter Friedl
5. Mina J. Bissell
6. Gerhard Christofori
7. E. Cukierman
8. Mahmut Yilmaz

Citations in the corpus

• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “epithelium triggers a cascade of events including the cleavage of E-cadherin resulting in epithelial-mesenchymal transition (Lochter et al., 1997; Radisky et al., 2005).”
• Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, positive): “For example, in breast cancer cells undergoing EMT in response to MMP-3 (which cleaves cell surface E-cadherin and thus weakens cell-cell junctions), the onset of migration depends on Rac activation and cell-derived production of reactive oxygen species (ROS), which in turn upregulate Snail (Radisky”
• Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways (2005, background): “Rac1b and reactive oxygen species (ROS) Very recent observations highlight a role of ROS in EMT (Radisky et al., 2005).”
• EMT, the cytoskeleton, and cancer cell invasion (2009, background): “Moreover, the expression of Snail1, the transcriptional repressor of Ecadherin gene expression and potent inducer of EMT, is is increased upon Rac1-mediated ROS production [143].”
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Matrix metalloproteinase (MMP)-3, a stromal enzyme that is up-regulated in many breast tumors, has been shown to induce ROS, DNA damage, genomic instability, and the transformation of mouse mammary epithelial cells into malignant cells (251).”
• The signaling mechanism of ROS in tumor progression (2007, neutral): “trigger EMT [150].”
• Stromal myofibroblasts are drivers of invasive cancer growth (2008, background): “A possible mechanism may be the induction of stromal-derived MMP-3 that is frequently upregulated in breast cancer, and that induces genomic instability through upregulation of reactive oxygen species (ROS).(101) Alternatively, mutated stromal cells might be cancer cells that have undergone epitheli”