Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer.

By T. Ueno, Masakazu Toi, H. Saji, M. Muta, H. Bando, K. Kuroi, M. Koike, H. Inadera, K. Matsushima. Clinical Cancer Research, 2000

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Role of chemokines in tumor growth. (2007, background): “In some studies, TAMs and CCL2 have been implicated to have pro-tumorigenic role.”
Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “Strong evidence demonstrates that levels of CCL2 are associated with TAM accumulation [2] and that CCL2 may play an important role in the regulation of angiogenesis [58].”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, unknown): “…has been suggested by the direct production of CCL2 by tumor cells (Bottazzi et al., 1983), the negative prognostic value of its expression levels (Ueno et al., 2000), and its significant correlation with the number of tumorassociated macrophages, which have been associated with enhanced…”
The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “CXCL1 and related molecules [CXCL2, CXCL3, CXCL8, or interleukin-8 (IL-8)] have an important role in melanoma progression by stimulating neoplastic growth, promoting inflammation, and inducing angiogenesis (19).”