Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.

By Brad Boeve, M. Silber, Clifford B. Saper, T. Ferman, D. Dickson, Joseph E. Parisi, E. Benarroch, J. Ahlskog, Glenn E. Smith, R. Caselli and 10 more. Brain : a journal of neurology, 2007

942 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/3f1c45db7089ad53c6f3a04ce2d55108791cfe00

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Brad Boeve
2. K. Del Tredici
3. C. Schenck
4. M. Mahowald
5. H. Braak
6. Ender Konukoglu
7. John Hardy
8. K. Jellinger

In Epidemiology

1. Brad Boeve
2. C. Schenck
3. M. Mahowald

In Neurology

1. K. Del Tredici
2. H. Braak
3. C. Hawkes
4. C. Schenck
5. M. Mahowald
6. Dennis W. Dickson

Citations in the corpus

• Neuroinflammation as a Common Feature of Neurodegenerative Disorders (2019, positive): “Another factor for evaluation is sleep disorders that are common in these diseases, the most common being called rapid eye movement (REM) sleep behavior disorder (RBD), representing between 30% and 46% of the cases for PD (Gagnon et al., 2002) and 50–80% of the cases for DLB (Boeve et al., 2007).”
• Parkinson's disease: a dual‐hit hypothesis (2007, background): “The pathophysiology is not understood fully but most likely reflects cellular changes found in the Parkinson neuropathological stages 1 and 2, involving the reticular formation, coeruleus/subcoeruleus complex, pedunculopontine nucleus and hypothalamus [80] .”
• Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. (2013, background): “The broader associations of RBD and synucleinopathies, such as PD emerging prior to or concurrent with the emergence of RBD, and the almost 100% link of MSA with RBD, and approximately 50% link of PD with RBD, have also received considerable attention [33,34–40,41,42].”
• REM Sleep Behavior Disorder: Updated Review of the Core Features, the RBD-Neurodegenerative Disease Association, Evolving Concepts, Controversies, and Future Directions (2010, background): “In the instances when (1) PSG cannot be performed for whatever reason, (2) PSG is performed and little or no apparent REM sleep is present, or (3) the EMG tone during REM sleep is equivocally elevated, this author would suggest the use of the term probable RBD for those who otherwise have a classic ”