Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

By S. Lai, D. O'Hanlon, S. Harrold, S. T. Man, Ying-Ying Wang, R. Cone, J. Hanes. Proceedings of the National Academy of Sciences of the United States of America, 2007

1,007 citations recorded by the source corpus.

Subfields: Biomaterials, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/f2a6a8a6587e4d74f91228a3264fe987f3667729

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. J. Hanes
2. A. D'Souza
3. R. Shegokar
4. Eric Lauga
5. E. Acosta

In Pharmaceutical Science

1. J. Hanes
2. L. Ensign
3. Ying-Ying Wang
4. S. Lai
5. Eric Lauga
6. R. Cone
7. J. Rodrigo Vélez-Cordero
8. Namho Kim

Citations in the corpus

• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “This approach has been taken to produce PEGylated PS NPs [130, 223], PEGylated dendrimers [149, 224-226], and PEGylated gold NPs [20, 227].”
• Applications and implications of nanotechnologies for the food sector (2008, background): “Researchers at the John Hopkins University, Maryland have recently published evidence to suggest that particl s as big as 200 nm can pass through mucus pores when coated with polyethylene glycol (a substance used commonly to coat drug particles to prevent uptake by phagocytic immune cells) (Samuel e”
• Barrier properties of mucus. (2009, background): “However, if polystyrene particles are densely coated with covalently attached polyethyleneglycol (PEG) they can readily diffuse through mucus: 500 nm PEGylated particles were slowed only 4 fold by cervico-vaginal mucus [39].”
• Waving transport and propulsion in a generalized Newtonian fluid (2013, methodology): “nd oscillatory ( ) measurements of human sputum [45]; oscillatory measurements inal mucus [47]; micro-rheological measurements ( ) of human lung mucus [48], reported in terms of oscillatory moduli, the Cox–Merz rule was applied to estimate .”
• Micro- and macrorheology of mucus (2009, positive): “This problem was resolved recently with the discovery that a low molecular weight polyethylene glycol coating can greatly reduce mucoadhesion [70].”
• Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues (2008, methodology): “(2 kDa) PEG, and studied their diffusion in fresh undiluted human mucus [17].”
• Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers (2011, background): “The authors attributed this effect to increased uptake of PLA-PEG particles across the intestinal epithelium.”
• Control of Polymeric Nanoparticle Size to Improve Therapeutic Delivery (2015, background): “This surface effect has also been demonstrated recently by engineering “mucus penetrating particles” of sizes from 100 to 500 nm [108].”
• Bioavailability of nanoparticles in nutrient and nutraceutical delivery (2009, background): “propose that the principles of size exclusion chromatography (SEC) can explain the slower movement of 100 nm particles along mucous layers [73].”