Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

By M. Stýblo, L. D. Del Razo, L. Vega, D. Germolec, E. LeCluyse, G. Hamilton, W. Reed, Changqing Wang, W. Cullen, D. Thomas. Archives of Toxicology, 2000

973 citations recorded by the source corpus.

Subfields: Environmental Chemistry, Health, Toxicology and Mutagenesis, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/f2a13540f8b7f5a3884d2381e197df8f9d11cd92

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In Environmental Chemistry

1. Virender K. Sharma
2. Weihua Chen
3. P. Finnegan
4. M. Sohn

In Health, Toxicology and Mutagenesis

1. K. Jomová
2. A. Hartwig
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Citations in the corpus

• Aquatic arsenic: toxicity, speciation, transformations, and remediation. (2009, background): “These trivalent arsenicals are more toxic than iAsV, MMAV, and DMAV in vitro (Styblo et al., 2000; Mass et al., 2001).”
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms (2008, background): “…methylated species, the trivalent methylated metabolites monomethylarsonous [MMA(III)] and dimethylarsinous [DMA(III)] acid in various test systems are at least as or even more genotoxic when compared to inorganic arsenic (Styblo et al. 2000; Schwerdtle et al. 2003a; Kligerman et al. 2003).”
• Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “As such, biomethylation serves as a detoxification process, and end products (methylated inorganic arsenic such as MMAV and DMAV excreted through urine) provide bioindications of chronic arsenic exposure (Table 2).”
• Advances in metal-induced oxidative stress and human disease. (2011, background): “, 2001) and that DMAIII is at least as cytotoxic as arsenite in everal human cell types (Styblo et al., 2000).”
• Arsenic: toxicity, oxidative stress and human disease (2011, background): “However, the process of methylation may lead to formation of reactive and carcinogenic trivalent methylated arsenicals (MMAIII and DMAIII; see above) (Cohen et al., 2001, 2002).”
• Arsenic Toxicity: The Effects on Plant Metabolism (2012, background): “The question of the source of methylated forms of As is important, as methylated forms of AsIII are more reactive and cytotoxic to animal cells than non-methylated forms (Styblo et al., 1997, 2000; Lin et al., 1999; Schwerdtle et al., 2003; Naranmandura et al., 2011).”