The many substrates and functions of ATM

By M. Kastan, D. Lim. Nature reviews. Molecular cell biology, 2000

835 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f299ea213cc96941e7dedd4b2b2553f53bcbdc4c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Stephen P. Jackson
2. N. Curtin

In Molecular Biology

1. G. Smith
2. Stephen P. Jackson
3. N. Curtin
4. Yosef Shiloh
5. J. Bartek
6. Y. Fouad
7. C. Aanei

In Oncology

1. Stephen P. Jackson
2. N. Curtin
3. Yosef Shiloh
4. Y. Fouad
5. C. Aanei

Citations in the corpus

• ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1 (2001, background): “Cell lines derived from patients lacking ATM are radiosensitive and exhibit defects in checkpoint responses to ionizing radiation (IR), including p53-dependent G1 cell cycle arrest and p53-independent S and G2 cell cycle arrests (31).”
• Toward maintaining the genome: DNA damage and replication checkpoints. (2002, background): “Identifying the targets of ATM phosphorylation will likely provide insight into the mechanism of checkpoint activation in response to DSBs [reviewed in (97)].”
• Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM (2004, background): “One of the hallmarks of A-T cells is their inability to mediate the G1-S–, intra-S–, and G2-M– phase DNA damage checkpoints in response to ionizing radiation (7, 9).”