Structure, function, and control of phosphoinositide-specific phospholipase C.

By M. Rebecchi, S. Pentyala. Physiological Reviews, 2000

979 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Plasma membrane phosphoinositide organization by protein electrostatics (2005, background): “Well-characterized phosphoinositide-specific phospholipase Cs (PLCs) hydrolyse PIP 2 into these second messenger”
Modelling of simple and complex calcium oscillations (2002, background): “Mechanisms for this coupling are the activating effect of Cacyt on the d isoform of PLC [43,63] and on the IP3 3-kinase (EC 2.”
Distinct coincidence detectors govern the corticostriatal spike timing‐dependent plasticity (2010, background): “…a coincidence detector involve elevation of calcium concentration, which is needed for its catalytic function, and its concomitant activation by Gq/11-coupled receptors, including group-I mGluRs, M1/M3 muscarinic and 5-HT2 serotoninergic receptors (5-HT2Rs) (Rebecchi & Pentyala, 2000; Rhee, 2001).”
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain (2005, background): “Coexpression of PLCδ1, the PLC isoform most sensitive to activation by calciu”
AKAP signalling complexes: focal points in space and time (2004, background): “, which generates DAG through hydrolysis of PtdIns(4,5)P 2 (Ref”
The trp ion channel family (2001, background): “Brief review of signal transduction The three classes of phosphatidylinositol-specific PLC (PLC-β 1–4 , PLC-γ 1,2 and PLC-δ 1–4 ) can be distinguished by their primary structure and modes of regulatio”