Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3

By S. Damak, M. Rong, K. Yasumatsu, Z. Kokrashvili, Vijayashree Varadarajan, Shiying Zou, Peihua Jiang, Y. Ninomiya, R. Margolskee. Science, 2003

617 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/f22c02f29cfb1256fcab4f6d13091f038fcc7d81

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In Biomedical Engineering

In Nutrition and Dietetics

In Sensory Systems

Citations in the corpus

The receptors for mammalian sweet and umami taste. (2003, background): “…but On the other hand, a number of studies with varioustheir tastant selectivity is determined by the nature of sugars and artificial sweeteners insinuate the possibilitythe receptors. of more than one sweet taste receptor (Schiffman et al., 1981; Ninomiya et al., 1999; Damak et al., 2003).”
Common Sense about Taste: From Mammals to Insects (2009, background): “As such, the T1Rs are lowaffinity receptors mediating behavioral preference thresholds in the millimolar range (Damak et al., 2003; Zhao et al., 2003); such low affinity helps the receptors distinguish between different potential sugar and protein sources without reaching saturation below…”
Genes and ligands for odorant, vomeronasal and taste receptors (2004, background): “Further functional insights came from the behavioural and whole-nerve electrophysiological characterization of T1R1 -, T1R2 - and T1R3 -knockout mic”
Umami Taste Responses Are Mediated by α-Transducin and α-Gustducin (2004, background): “KO mice lacking T1r1 and/or T1r3 have greatly reduced responses to umami compounds (Damak et al., 2003; Zhao et al., 2003).”
The cell biology of taste (2010, background): “Nevertheless, robust physiological responses and behavioral preference for umami tastants persist in mice in which T1R3 is knocked out, suggest ing that additional taste receptors may contribute to umami de tection (Damak et al., 2003; Maruyama et al., 2006; Yasumatsu et al., 2009).”
Mammalian G proteins and their cell type specific functions. (2005, background): “In addition, T1R3 may form homodimers that can also mediate some sweet tastes, and there is evidence that also a splice variant of the mGluR4 glutamate receptor may be involved in umami sensation (95, 96, 127, 730).”
The receptors and cells for mammalian taste (2006, background): “Definitive proof that T1R2p3 is the principal mammalian sweet taste receptor was obtained from studies of T1r2 - and T1r3 -knockout mic”