Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

By J. Rioux, Mark J. Daly, M. Silverberg, K. Lindblad, H. Steinhart, Z. Cohen, T. Delmonte, Kerry Kocher, Katie Miller, Sheila Guschwan and 21 more. Nature Genetics, 2001

816 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/f1ebad61dbf33f7e2f58bbdb2fbae05769711a30

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Matthew Stephens
2. Gonçalo R. Abecasis
3. Jonathan Marchini
4. Peter Donnelly
5. Mark J. Daly
6. Sharon R. Browning
7. Brian L. Browning
8. David Altshuler

In Immunology

1. Matthew Stephens
2. Robert M. Plenge
3. M. Boldin
4. K. Taganov

In Surgery

1. Mark J. Daly
2. David Altshuler

Citations in the corpus

• Genetic association studies: Design, analysis and interpretation (2002, background): “containing a gene cluster.(5) However, genome-wide association studies will be feasible when we have a clearer understanding of genetic variation in the human genome, and when genotyping throughput has increased substantially.”
• Haploview: analysis and visualization of LD and haplotype maps (2005, background): “…in disease association and positional cloning studies is becoming increasingly widespread since it has become clear (Van Eerdewegh et al., 2002; Rioux et al., 2001; Geesaman et al., 2003; Stoll et al., 2004) that intelligent use of this information has the potential to make them much more…”
• Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. (2005, background): “We selected seven alleles from five additional genes with convincing evidence of causality in either inflammatory bowel disease (CARD15 [Hugot et al. 2001; Ogura et al. 2001], DLG5 [Stoll et al. 2004], and IBD5 [Rioux et al. 2001; Daly and Rioux 2004]) or type 1 diabetes (SUMO4 [Guo et al. 2004] and”
• A review on SNP and other types of molecular markers and their use in animal genetics (2002, background): “Indeed, many SNPs will have equivalent association properties within a highly conserved common haplotype [66].”
• A haplotype map of the human genome. (2003, background): “(27) in their analysis of Crohn’s disease.”
• miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice (2011, background): “, 2003), Crohn’s disease (Rioux et al., 2001), asthma (Kauppi et al.”