Obesity is associated with hypothalamic injury in rodents and humans.
By J. Thaler, C. Yi, E. Schur, Stephan J Guyenet, B. Hwang, M. Dietrich, Xiaolin Zhao, D. Sarruf, Vitaly Izgur, K. Maravilla and 9 more. Journal of Clinical Investigation, 2012
1,695 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Epidemiology, Neurology
View Paper: https://www.semanticscholar.org/paper/778507bf4fe48874e3af5fb3b7af8c1888714444
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In Epidemiology
Citations in the corpus
- Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “A recent study showed that the hypothalamus of obese humans and of experimental models of obesity presents signs of inflammation and dysfunction that precede the installation of increased adiposity and T2D (15).”
- Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity (2017, background): “As an early event in obesity development and even within a few days of ingesting a high-fat, calorie-dense diet, an increased amount of saturated fatty acids (FAs) from the periphery crosses the BBB and induces an inflammatory response in hypothalamic neurons (Thaler et al., 2012).”
- 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “Arcuate 11 -HSD1 is acutely induced by high-fat feeding (149), with the timing suggesting this may be part of the acute inflammatory hypothalamic response to high-fat diet (702).”