Determinants of BRAF mutations in primary melanomas.

By J. Maldonado, Jane Fridlyand, Hetal Patel, Ajay N. Jain, K. Busam, T. Kageshita, T. Ono, Donna Albertson, Dan Pinkel, B. Bastian. Journal of the National Cancer Institute, 2003

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Array comparative genomic hybridization and its applications in cancer (2005, background): “Genes that drive copy-number gains may also be altered by mutatio”
MAP kinase signalling pathways in cancer (2007, background): “Curiously, in melanoma this mutation is rare in unexposed or chronically sundamaged skin, but frequent in skin with intermittent sun exposure and often accompanied by amplification of the mutant allele (Maldonado et al., 2003).”
Reduced melanoma after regular sunscreen use: randomized trial follow-up. (2011, result): “The results are consistent with the knowledge that excessive sun exposure causes melanoma,(5) notwithstanding the evidence that solar UV carcinogenesis may operate by different pathways to cause melanomas on different body sites.(28,29) Results also accord with background experimental data in mice,(”