Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.

By E. Nemeth, E. Valore, M. Territo, G. Schiller, A. Lichtenstein, T. Ganz. Blood, 2003

1,475 citations recorded by the source corpus.

Subfields: Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/f181470bd7876ed5db4621f36f3f001caa5ed11e

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In Genetics

1. T. Ganz
2. E. Nemeth
3. A. Pietrangelo
4. S. Rivera
5. B. K. Pedersen
6. C. Keller
7. V. Gabayan
8. S. Taudorf

In Hematology

1. T. Ganz
2. E. Nemeth
3. R. Hurrell
4. A. Pietrangelo
5. S. Rivera
6. B. K. Pedersen
7. C. Keller
8. V. Gabayan

Citations in the corpus

• IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial (2008, background): “25 26 The correction of anaemia seen with TNF antagonists thus potentially occurs indirectly via a reduction in IL-6 levels, 27 whereas tocilizumab directly inhibits IL-6 signalling for each mechanism.”
• BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism (2009, positive): “Hepcidin is also upregulated by inflammatory cytokines, and hepcidin excess is implicated in the pathogenesis of anemia of inflammatio”
• IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004, positive): “We previously showed in human hepatocyte culture (12) that hepcidin is induced by IL-6, but not IL-1 or TNF-α , indicating”
• Immunoassay for human serum hepcidin. (2008, neutral): “Ferritin 109 (42-398) 39 (13-85) 118 (15-288) 46 (18-140)”
• Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis (2004, background): “Deleterious mutations of hemojuvelin reduce hepcidin levels despite iron overload, which normally induces hepcidin expressio”
• Systemic iron homeostasis. (2013, background): “Subsequently, microbial molecules, the plant-derived inflammatory agent turpentine, and cytokines were shown to be potent inducers of hepcidin synthesis (162, 165, 168, 186).”
• Iron bioavailability and dietary reference values. (2010, background): “Hepcidin expression is increased in chronic inflammation and obesity (66, 68) and may contribute to the increased prevalence of iron deficiency observed in overweight populations (69, 70).”