Bone marrow–derived stem cells initiate pancreatic regeneration

By David Hess, Li Li, Matthew Martin, S. Sakano, D. Hill, B. Strutt, S. Thyssen, D. Gray, M. Bhatia. Nature Biotechnology, 2003

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Increased Number of Islet-Associated Macrophages in Type 2 Diabetes (2007, background): “marrow cells home to damaged βcells in a peri-islet fashion to promote islet regeneration (26).”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “This strategy may represent a previously unrecognized means by which bone marrowderived cells can contribute to tissue restoration (156).”
Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. (2004, background): “That the local production of factors by stem cells may occur and play a role in tissue repair has been suggested by data in a mouse model of pancreatic regeneration (50).”
Stem cell plasticity: time for a reappraisal? (2005, neutral): “The fact that Y, GFP-negative pancreatic cells were found suggests that no fusion had occurred.(31,32) Hess et al.”
Plasticity of marrow-derived stem cells. (2003, positive): “This effect was not due to the irradiation as those mice that were irradiated and given PBS showed hyperglycemia and hypoinsulinemia similar to STZ-treated control animals.(61) Although marrow-derived (GFP+) pancreatic beta cells comprised 2.”