Receptor Specificity of the Fibroblast Growth Factor Family
By Xiuqin Zhang, O. Ibrahimi, S. Olsen, H. Umemori, M. Mohammadi, D. Ornitz. Journal of Biological Chemistry, 2006
674 citations recorded by the source corpus.
In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The spatial and temporal expression patterns of FGFs and FGFRs and the ability of specific ligand-receptor pairs to actively signal are important factors regulating FGF activity in a variety of biological processes. FGF signaling activity is regulated by the binding specificity of ligands and receptors and is modulated by extrinsic cofactors such as heparan sulfate proteoglycans. In previous studies, we have engineered BaF3 cell lines to express the seven principal FGFRs and used these cell lines to determine the receptor binding specificity of FGFs 1–9 by using relative mitogenic activity as the readout. Here we have extended these semiquantitative studies to assess the receptor binding specificity of the remaining FGFs 10–23. This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f15e9d1b0fb4982bf4a3f197e235735d70240b86
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Citations in the corpus
- Keratinocyte-fibroblast interactions in wound healing. (2007, background): “Recently, another FGF family member, FGF22, has been identified, which also can activate FGFR2IIIb (Zhang et al., 2006).”
- Fibroblast growth factor signalling: from development to cancer (2010, background): “The specificity of the FGF–FGFR interaction is established partly by the differing ligand-binding capacities of the receptor paralogue”
- Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (2011, neutral): “The binding specificity of FGFs to FGFRs is partly dictated by the receptor isoform (Ornitz et al .”