Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans1

By G. Buchman, Irene E. Karl, F. Osborne, Bradley D. Freeman, J. Cobb, Timothy, R. Schmieg, J. Hui, Katherine C. Chang, Dale and 3 more. Journal of Immunology, 2001

944 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f148064d45868d80e295c1b58b276f06fc6c2c97

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In Epidemiology

D. Remick

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Citations in the corpus

Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care (2012, neutral): “Adaptive Immunity Changes in Severe Sepsis and Trauma Adaptive Immune Changes Reference(s) Increased Tregs Monneret et al.49 T-cell anergy Bone et al.,28 Bone39 T-cell polarization-shift from TH1 to TH2 phenotype Delano et al.50 Macrophage paralysis Munoz et al.,51 Ayala and Chaudry52Decreased cytok”
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure (2011, neutral): “0) [24-84] Sex Male 17 Female 12 Admission diagnosis Motor vehicle collision, head trauma 1”
The Pathogenesis of Sepsis (2011, result): “Subsequent studies in spleens of septic patients by the same group (9, 44) revealed that B cell and CD4+ T subsets of lymphocytes and dendritic cells (both follicular and interdigitating) were especially vulnerable to apoptosis, whereas other T cell subsets and macrophages remained largely intact.”
MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis (2007, background): “Reduced CD4+ T cell numbers caused by apoptosis-induced depletion (3, 4) and a suppression of T cell proliferative responses (5) have been shown to contribute to sepsis-associated morbidity.”