Guilt by association

808 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, background): “Another example from type 2 diabetes is the frequent PPAR-g Pro12Ala polymorphism, for which a meta-analysis of 13,000 individuals was necessary to resolve apparently conflicting studies (Altshuler et al. 2000b).”
Network-based methods for human disease gene prediction. (2011, background): “The underlying assumption is ‘guilt-by-association’, in that, genes that are physically or functionally close to each other tend to be involved in the same biological pathways and have similar effects on phenotypes [31, 32].”
Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits (2004, methodology): “Meta-analysis has been used successfully to both confirm [Altshuler et al., 2000; Faraone et al., 2001] and refute [Kluger et al., 2002; Lalovic and Turecki, 2002] putative associations between genetic variants and complex traits.”