Autophagy and human diseases

By Peidu Jiang, N. Mizushima. Cell Research, 2013

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The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “Diminished autophagic activity plays a major role in aging and age-related diseases [92].”
Autophagy and autophagy-related proteins in cancer (2020, background): “In diseases, such as neurodegenerative diseases [165, 166], infectious diseases [11, 167, 168], and metabolic diseases [14], dysfunctional autophagy leads to the accumulation of abnormal and damaged proteins and organelles and formation of intracellular aggregates, and then prevents the ability of a”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Lysosomal dysfunction is associated with age-related pathology that reduce lifespan, such as Parkinson’s and Alzheimer’s diseases (70, 71).”