Faculty Opinions recommendation of Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

By J. Pieters. 2006

2,510 citations recorded by the source corpus.

Subfields: Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/f09cefb210a504107df8786d8cb5f5135f53a3e5

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In Pathology and Forensic Medicine

1. M. Wacker
2. N. Charoenngam
3. R. Nair
4. A. Maseeh
5. D. Bikle
6. G. Weiss
7. Dominic Tang
8. R. Modlin

Citations in the corpus

• Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin1 (2007, methodology): “THP-1 cells were incubated for 18 h with 1,25D3 and their cathelicidin and -actin levels were assessed using intracellular flow cytometry as previously described (3, 8).”
• Vitamin D and Immune Function (2013, background): “tuberculosis show a strong induction of the 1α-hydroxylase CYP27B1 and the vitamin D receptor after recognizing pathogens by toll-like receptors, leading to a direct modulation of gene expression, favoring production of cathelicidin [43].”
• Nonclassic actions of vitamin D. (2009, background): “When macrophages are activated via specific tolllike receptors (TLRs), CYP27B1 is induced (14).”
• Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “which increases the local production of 1,25(OH)2D that is dependent on the serum 25(OH)D concentration [145,228].”
• Macrophage defense mechanisms against intracellular bacteria (2015, background): “The expression of this latter receptor as well as the vitamin D converting hydroxylases, mainly vitamin D-1 hydroxylase CYP27b1, is induced after TLR2 activation of human monocytes/macrophages (82).”
• Immunologic Effects of Vitamin D on Human Health and Disease (2020, background): “Then, 1,25(OH)2D enhances antimicrobial activities of macrophages and monocytes in an autocrine fashion via VDR-RXR s gnaling, which, in turn, stimulates the productio of e dogen us antimicrobial cathelicidin LL-37 [1,2,5,17,18].”
• Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1 (2012, background): “rectly induce the production of the important antimicrobial peptides, cathelicidin and human b defensin 4, by human monocytes/ macrophages and epithelial cells (23, 35).”
• Vitamin D: The “sunshine” vitamin (2012, background): “In this context, extrarenal 1,25(OH)2D productions in macrophages are stimulated by Toll-like receptor as part of the innate immune response against intracellular bacteria.[68] Another example of extrarenal regulation of 1α-hydroxylase is that the increased production of 1,25(OH)2D by keratinocytes ”
• Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 (2009, background): “Although the mechanisms controlling LL37 expression are still poorly understood, recent studies revealed the key involvement of the vitamin D3 and hypoxia response pathways, as well as the effect of various microorganisms on the production of LL37 (Liu et al., 2006; Schauber et al., 2007; Peyssonnau”
• Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form (2008, background): “Recent studies have shown that in monocytes/macrophages and in keratinocytes TLR2 ligands induce 1 -hydroxylase and lead to up-regulation of the vitamin D-regulated gene, cathelicidin (6, 25).”