Control of T‐cell activation by CD4+ CD25+ suppressor T cells

By E. Shevach, R. McHugh, C. Piccirillo, A. Thornton. Immunological Reviews, 2001

631 citations recorded by the source corpus.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/f050167a8fcc86579b4b410b8f5d17224a5b750f

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In Immunology

1. S. Rosenberg
2. E. Shevach
3. N. Restifo
4. C. Piccirillo
5. Jie Yang
6. A. Thornton
7. David A. Hafler
8. R. McHugh

Citations in the corpus

• The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. (2006, background): “Functionally, Treg cells can prevent the activation or expansion of both CD41 and CD81 T cells through mechanisms that are still poorly understood, but could involve the secretion of suppressive cytokines (IL-10 or TGF-b), the restraining of antigen-presenting capacity, or mediation of cell-to-cell ”
• Cytokines in cancer pathogenesis and cancer therapy (2004, background): “Regulatory T cells, a key population that controls effector T cells and helps maintain tolerance to self antigens, also constitutively express surface CTLA-4 (Ref”
• Cancer immunotherapy: moving beyond current vaccines (2004, background): “Recent research has emphasized the importance of active suppressor mechanisms arising both from the tumor and from the immune system itself that can inhibit antitumor immune reactions in viv”
• Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis (2004, background): “Active suppression by regulatory T cells plays a key role in the control of self-antigen–reactive T cells and the induction of peripheral tolerance in vivo (3, 4).”
• Cytokines in Cancer Immunotherapy (2011, background): “autoimmune colitis [74,76-78], providing additional evidence of the role of IL-2 not only as an activator of immune responses but also as a key mediator of immune tolerance.”
• CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness (2002, background): “It is widely accepted that this population of suppressor cells mediates its function in vitro by a direct cell contact‐dependent mechanism that is independent of the above-mentioned secreted suppressor cytokines (5, 39 ).”