Role of Dicer and Drosha for Endothelial MicroRNA Expression and Angiogenesis

By Angelika Kuehbacher, C. Urbich, A. Zeiher, Stefanie Dimmeler. Circulation Research, 2007

825 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f01c60d15ed3340b5aae98e466fdd076ffe216ec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. E. Olson
2. Marilena V. Iorio
3. Stefanie Dimmeler
4. A. Zeiher
5. Carlo Maria Croce
6. Danish H Sayed
7. M. Abdellatif
8. J. Richardson

In Molecular Biology

1. E. Olson
2. Stefanie Dimmeler
3. Marilena V. Iorio
4. R. Bassel-Duby
5. A. Zeiher
6. J. Richardson
7. C. Urbich
8. X. Qi

Citations in the corpus

• MicroRNAs in development and disease. (2011, background): “This was confirmed by the knockdown of Dicer in human umbilical vascular endothelial cells (HUVEC), which exhibited defective proliferation, migration, and tubulogenesis (321, 584).”
• Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Surprisingly, critical regulators of angiogenesis such as vascular endothelial growth factor (VEGF) and its receptor Flt1 were upregulated after Dicer depletion.(26,27) The VEGF-R2 (KDR) was upregulated in one study(26) but was not affected in another study,(27) which might suggest that this regulat”
• Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs (2012, methodology): “Lipofectamine RNAiMAX (Invitrogen) was used to transfect HASMCs with cel-miR-39 (10 nM or 100 nM final concentration) and with siRNA targeting Drosh”
• MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. (2008, neutral): “MicroRNAs Direct Cell Fate in Embryonic Stem Cells specifically in the early precardiac mesoderm at this early stage (Figure 1B), while the vascular endothelium-enriched miRNA, miR-126, was absent (Kuehbacher et al., 2007).”
• MicroRNAs in cancer: small molecules with a huge impact. (2009, background): “Angiogenesis can be also promoted by miR-210, activated by hypoxia and directly repressing endothelial ligand ephrin A3,(79) and by miR-17-92 cluster, which sustains MYC angiogenic properties through repression of connective tissue growth factor and the antiangiogenic adhesive glycoprotein thrombosp”
• An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “miRNAs have been implicated in regulating EC gene expression and function in vitro (Kuehbacher et al., 2007; Suarez et al., 2007), but the functions of miRNAs in EC biology in vivo have not been explored.”
• MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “…ligand Ephrin A3 (Pulkkinen et al, 2008). miR-17-92 cluster sustains MYC angiogenic properties by repressing connective tissue growth factor (CTGF) and anti-angiogenic adhesive glycoprotein thrombospondin 1 (TSP1; Dews et al, 2006), also targeted by miR-27b and let-7f (Kuehbacher et al, 2007).”