The microRNA spectrum in 12 body fluids.

By Jessica A. Weber, D. Baxter, Shile Zhang, David Huang, Kuo-How Huang, Ming‐Jen Lee, D. Galas, Kai Wang. Clinical Chemistry, 2010

2,655 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b0a37c8cefd8a3db13a8179cb892ab9c253dda4c

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Citations in the corpus

Changes in circulating microRNA levels associated with prostate cancer (2012, background): “MicroRNAs may be useful biomarkers as their relatively small size protects them from RNase attack and they are secreted within protective exosomes (Weber et al, 2010).”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “cerebrospinal fluid and synovial fluid, placenta and breast milk) 204 , which makes these molecules suitable for liquid biopsy applications. microRNAs were recently found to be selectively inserted in extracellular vesicles that also display a moderate content of small ncRNAs, the distribution and…”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “They are secreted by numerous cells, both in vitro and in vivo and can be encountered in most of the fluids in the body [30,34].”
Comparing the MicroRNA Spectrum between Serum and Plasma (2012, methodology): “For serum or plasma, total RNA was extracted from 100 ml of the sample using the miRNeasy kit (Qiagen, Valencia, CA) as previously described [6,12].”
Circulating MicroRNAs as a Novel Class of Diagnostic Biomarkers in Gastrointestinal Tumors Detection: A Meta-Analysis Based on 42 Articles (2014, background): “It has been observed that miRNAs could present extensively in the cell-free body fluids and excretions, including serum, plasma, urine, tears, saliva, bronchial lavage, and feces, etc [17].”
The Host Shapes the Gut Microbiota via Fecal microRNA (2016, positive): “However, increasing evidence demonstrates that miRNAs exist extracellularly and circulate in body fluids (Weber et al., 2010).”
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “” The observation that miRNAs could be secreted by a solid tumor into the surrounding environment and that they are stable in body fluids make miRNAs promising targets easily found in blood, plasma, and serum [207].”
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “Concurrent studies demonstrated the presence of miRNAs in bodily fluids (Weber et al., 2010) and associated their levels to disease progression (see below).”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “MicroRNAs in Biological Fluids Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovar”
The Potential for microRNA Therapeutics and Clinical Research (2019, background): “…used to indicate presence of a pathology and even the stage, progression, or genetic link of pathogenesis (Kocerha et al., 2011; Wang et al., 2011, 2015; Weir et al., 2011; Elfimova et al., 2012; Li et al., 2013; Recchioni et al., 2013; Scott et al., 2015; Biswas, 2018; Hu et al., 2018).”
Factors affecting the composition of the gut microbiota, and its modulation (2019, background): “, 2014), and it has been proven that miRNAs exist outside the cells and circulate in bodily fluids (Weber et al., 2010).”