TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

By M. Belghith, J. Bluestone, Samia Barriot, Jérôme Mégret, J. Bach, L. Chatenoud. Nature Medicine, 2003

656 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/efac532d49992ea46e83d8f0e118a40d62a28eb5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. B. Fife
2. J. Bluestone

In Immunology

1. B. Fife
2. Steven F. Ziegler
3. M. Battaglia
4. A. Tedgui
5. Z. Mallat
6. J. Bluestone
7. M. Levings
8. Shimon Sakaguchi

Citations in the corpus

• Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “In contrast, in murine studies, anti-CD3 monoclonal antibody treatment has been shown to induce CD4CD25 Tregs, which suppress through a TGF-b -dependent mechanism (80).”
• Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways (2008, background): “Anti-CD3 therapy has been shown to induce tolerance by at least two distinct mechanisms: autoreactive T-cell death through the induction of apoptosis and Treg suppression (86).”
• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells (2006, background): “Moreover, there are several therapeutic interventions that appear to promote T reg cell development and function (10, 11).”
• A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes (2005, background): “More recent studies suggest that the prolonged duration of the therapeutic effect may involve the induction of regulatory T-cells that can control autoimmune responses through a transforming growth factor- – dependent mechanism (13).”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “TGF- mediates, at least in part, the suppressive function of natural Treg in vivo and under certain culture conditions in vitro (44, 120, 251).”