The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape.

By Michael Kühl, L. C. Sheldahl, Maiyon Park, Jeffrey R. Miller, R. Moon. Trends in Genetics, 2000

960 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ef262d85b64370815c3fdbcef6ab2bd3fb5847a8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Secreted antagonists of the Wnt signalling pathway (2003, background): “…Wnts (e.g. Wnt4, Wnt5A and Wnt11) activate other signalling pathways, such as the planar-cell-polarity (PCP)-like pathway that guides cell movements during gastrulation (Heisenberg et al., 2000) and the Wnt/Ca2+ pathway (discovered in zebrafish and Xenopus) (reviewed in Kuhl et al., 2000).”
The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling (2003, background): “In contrast, Wnt-5a and Rfz-2 both stimulate Ca2 release and activate CaMKII ( 11 , 12, 27, 28).”
INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, positive): “After having named this WNT-induced and G protein-dependent pathway WNT/Ca pathway (Kuhl et al., 2000), PTX-sensitive and rapid Ca release upon WNT stimulation has been shown to be functional in several cellular systems (Sheldahl et al.”
Androgen receptor (AR) coregulators: an overview. (2002, background): “In addition to this structural role, -catenin is a downstream effector of the Wnt signaling pathway that regulates a number of cellular processes including cellular differentiation, proliferation, and migration (167).”
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, methodology): “However, our observation that Wnt-5a–induced -catenin inhibition was not rescued by blocking NF-AT or CaMKII activation argues that there may be a NF-AT– and CaMKII-independent pathway that is activated by Wnt-5a signaling to promote -catenin degradation in 293 cells.”
The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling (2002, background): “2000); (2) the planar cell polarity pathway (Wnt/JNK pathway) depends on JNK activity and controls cytoskeletal rearrangements (Mlodzik 2000; Sokol 2000); (3) the Wnt/Ca pathway controls PKC and CamKII and regulates cell adhesion and motility (Kuhl et al. 2000; Winklbauer et al. 2001); and (4) a not”