ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

By L. Toledo, M. Altmeyer, M. Rask, C. Lukas, D. Larsen, L. Povlsen, Simon Bekker-Jensen, Niels Mailand, J. Bartek, J. Lukas. Cell, 2013

885 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eefc765c11d4d15c208581c19488ab827cad99fa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Stephen P. Jackson
2. Andrew N. Blackford
3. Morgane Macheret
4. T. Halazonetis
5. J. Bartek
6. Yosef Shiloh
7. Y. Fouad
8. C. Aanei

Citations in the corpus

• DNA replication stress as a hallmark of cancer. (2015, positive): “In one study, U2OS cells were treated with the Wee1 inhibitor MK-1775 to enhance origin firing and, in parallel, fork progression was challenged with hydroxyurea (98).”
• ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response. (2017, positive): “This is important to avoid exhaustion of replication and repair factor pools, particularly RPA (Toledo et al., 2013).”