ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

By Andrew N. Blackford, Stephen P. Jackson. Molecules and Cells, 2017

1,689 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eac24adc269990b399f44572f8271f277b37c05f

How researchers see this paper

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In Cancer Research

1. Pingkun Zhou
2. Karlene A. Cimprich

In Molecular Biology

1. Ruixue Huang
2. Pingkun Zhou
3. Karlene A. Cimprich

Citations in the corpus

• Olaparib for Metastatic Castration-Resistant Prostate Cancer. (2020, neutral): “Adverse event Any 244 (95) 130 (51) 114 (88) 49 (38) Anemia† 119 (46) 55 (21) 20 (15) 7 (5) Nausea 106 (41) 3 (1) 25 (19) 0 Fatigue or asthenia 105 (41) 7 (3) 42 (32) 7 (5) Decreased appetite 77 (30) 3 (1) 23 (18) 1 (<1) Diarrhea 54 (21) 2 (<1) 9 (7) 0 Vomiting 47 (18) 6 (2) 16 (12) 1 (<1) Constipat”
• DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “For example, multiple families including ATM (ATM serine/protein kinase), ATR (ATR serine/threonine kinase), and DNA-PKcs (DNA-dependent protein kinase catalytic subunit) can initiate the signaling cascade in mammalian cells.(66) A recent review by Monique PCM et al.”
• R-loops as cellular regulators and genomic threats (2019, background): “As central regulators of the DNA damage response (DDR), the ATR and ATM protein kinases orchestrate responses to replication fork slowdown or stalling (replication stress), and to DSBs respectively (Blackford and Jackson, 2017; Saldivar et al., 2017).”