Theta-Gamma-Modulated Synaptic Currents in Hippocampal Granule Cells In Vivo Define a Mechanism for Network Oscillations
By A. Pernía-Andrade, Peter Jonas. 2014
218 citations recorded by the source corpus.
Summary Theta-gamma network oscillations are thought to represent key reference signals for information processing in neuronal ensembles, but the underlying synaptic mechanisms remain unclear. To address this question, we performed whole-cell (WC) patch-clamp recordings from mature hippocampal granule cells (GCs) in vivo in the dentate gyrus of anesthetized and awake rats. GCs in vivo fired action potentials at low frequency, consistent with sparse coding in the dentate gyrus. GCs were exposed to barrages of fast AMPAR-mediated excitatory postsynaptic currents (EPSCs), primarily relayed from the entorhinal cortex, and inhibitory postsynaptic currents (IPSCs), presumably generated by local interneurons. EPSCs exhibited coherence with the field potential predominantly in the theta frequency band, whereas IPSCs showed coherence primarily in the gamma range. Action potentials in GCs were phase locked to network oscillations. Thus, theta-gamma-modulated synaptic currents may provide a framework for sparse temporal coding of information in the dentate gyrus.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
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Citations in the corpus
- Sparse activity of identified dentate granule cells during spatial exploration (2016, background): “…the complex cone-shape of the dendritic arbor and, in the few cases where axons were recovered (e.g. Figure 3A), the presence of long-range axons and mossy boutons (Ambrogini et al., 2004; Schmidt-Hieber et al., 2004; Espósito et al., 2005; Zhao et al., 2006; Pernı́a-Andrade and Jonas, 2014).”
- Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding (2016, unknown): “…to a similar degree d abGCs actively participate in the encoding of novel information Authors Nathan B. Danielson, Patrick Kaifosh, Jeffrey D. Zaremba, ..., René Hen, Attila Losonczy, Mazen A. Kheirbek Correspondence al2856@cumc.columbia.edu In Brief Danielson et al. monitored and…”
- Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function (2014, background): “This computation could be particularly important in the dentate gyrus, where it may contribute to sparsification of activity (78), pattern separation (79), and grid-to-place code conversion (77, 80).”