Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
By Kerry L Donnelly, Coleman I. Smith, S. Schwarzenberg, J. Jessurun, M. Boldt, E. Parks. Journal of Clinical Investigation, 2005
3,384 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/ed7633369ab77ee37699d391fe0fa59627da0df8
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In Epidemiology
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Citations in the corpus
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009, background): “Our data suggest that the increase in VLDL-TG secretion rate in obese subjects who have NAFLD is primarily caused by the availability of nonsystemic fatty acids derived from lipolysis of IHTG, not VAT, because VAT volume was the same in both groups and de novo lipogenesis accounts for up to 20% of t”
- Increased de novo Lipogenesis is a Distinct Characteristic of Individuals with Nonalcoholic Fatty Liver Disease (2013, neutral): “Using an established multiple stableisotope procedure,(12,14,16,19) the potential FA sources that contribute to production of lipoprotein-TG palmitate (dietary fat, adipose FA, and hepatic lipogenesis) were each labeled with a different palmitate isotope and expressed as both absolute concentration ”
- Why Does Obesity Cause Diabetes? (2022, neutral): “(Duckworth et al., 1998).”
- Overproduction of large VLDL particles is driven by increased liver fat content in man (2006, background): “Indeed, increased delivery of NEFA to the liver in humans is associated with fatty liver [29, 30] and has been linked to hepatic insulin resistance [31–33].”
- Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease (2016, background): “A more recent analysis of obese patients with NAFLD found that while 60 % of liver triglycerides are derived from plasma free fatty acid, which themselves are derived from adipose tissue lipolysis, 26 % of liver fat in these individual came from DNL and another 15 % from dietary fat [44].”
- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis (2010, background): “Free fatty acid delivery to the liver accounts for almost two-thirds of its lipid accumulation.(12) Abbreviations: AhR, aryl hydrocarbon receptor; ATF-6, activating transcription factor 6; ChREBP, carbohydrate response element-binding protein; DGAT, diacylglycerol acyltransferase; DNL, de novo lipog”
- Triglyceride metabolism in the liver (2017, neutral): “However, in addition to the enhanced FA uptake, increased DNL can contribute substantially to hepatic steatosis (72).”
- Mechanisms and disease consequences of nonalcoholic fatty liver disease (2021, background): “, chylomicron remnants, low-density lipoprotein [LDL]), which occur with increased plasma concentrations of ApoC3, as well as from circulating fatty acids, a major source for hepatic triglyceride synthesis (Donnelly et al., 2005).”
- The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome (2010, background): “but stable isotope studies have demonstrated that up to only 15% of intrahepatic lipid is derived from dietary fat”