Structure and Mechanism of the Lactose Permease of Escherichia coli

By J. Abramson, I. Smirnova, V. Kasho, G. Verner, H. Kaback, S. Iwata. Science, 2003

1,426 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ed291140a3d83e3a94c27840427639fdf78b3a80

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In Food Science

H. Nikaido

Citations in the corpus

Membrane-protein topology (2006, background): “Small-molecule transporters such as lactose permease and the glycerol-3-phosphate transporter are also thought to undergo extensive repacking of their transmembrane helices during substrate transpor”
Functional biology of plant phosphate uptake at root and mycorrhiza interfaces. (2007, background): “The three-dimensional structures of oxalate (OxlT), lactose (LacY) and glycerol-3-phosphate/inorganic phosphate (GlpT) transporters from Oxalobacter formigens and Escherichia coli, respectively, have been elucidated; these demonstrate the presence of 12 transmembrane domains, substantiating the stru”
How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria (2006, background): “The recently resolved LacY structure confirms previous predictions that the protein contains 12 hydrophobic transmembrane domains connected by relatively hydrophilic loops (4).”
Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “[71] To date, crystal structures are available for several MFS transporters such as the lactose/H+ permease LacY,[72] the glycerol-3-phosphate transporter GlpT[73] and the multidrug transporter EmrD,[60] which are all from E. coli.”
A glimpse of structural biology through X-ray crystallography. (2014, background): “coli (Abramson et al., 2003) and the glycerol-3-phosphate transporter GlpT (Huang et al.”
The SLC2 (GLUT) Family of Membrane Transporters (2013, neutral): “…members of the MFS, have thus far proven recalcitrant to crystallization, but the crystal structures of 4 bacterial members of the MFS have been determined to at least moderate resolution by x-ray diffraction analysis (Abramson et al., 2003; Dang et al., 2010; Huang et al., 2003; Yin et al., 2006).”
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside (2003, background): “Opening and closing channels through helix bending was also proposed for other protein”
Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action. (2013, methodology): “Preliminary efforts to understand the structure and function of SERT involved homology modeling of these transporters using the crystal structures of distant members of the major facilitator superfamily, such as lactose permease symporter, as template (Abramson et al., 2003; Ravna et al., 2006).”