The role of autophagy in neurodegenerative disease

By Ralph A. Nixon. Nature Medicine, 2013

1,985 citations recorded by the source corpus.

Subfields: Epidemiology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/ed28204aee9343e5e7a1279427882db0b6ab5f67

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Citations in the corpus

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “OVERVIEW OF AUTOPHAGY Eukaryotic cells utilize autophagy for maintaining homeostasis and managing lipid metabolism.(44,45) Activated by various stress states, autophagic membrane structures are formed to engulf and degrade intracellular structures, including damaged organelles, unfolded proteins, an”
Hallmarks of neurodegenerative diseases. (2023, positive): “129,131,132 Mutations in the SQSTM1 gene encoding the p62 protein, which links UPS and ALP by binding ubiquitin and targeting cargo to the ALP, give rise to ALS/FTD cases.”
Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms (2017, background): “Cell culture and animal models of AD have demonstrated excessive fission of mitochondria concomitant with accumulation of dysfunctional mitochondria, possibly as the result of lysosomal dysfunction [63, 77].”
Amyloid Precursor Protein (APP)/APP-like Protein 2 (APLP2) Expression Is Required to Initiate Endosome-Nucleus-Autophagosome Trafficking of Glypican-1-derived Heparan Sulfate* (2014, neutral): “Staining with anti-LC3, a recognized marker for autophagosomes (30), also revealed extensive (approximately 87%) colocalization with the anMan-stained HS degradation products at paranuclear sites (Fig.”
PI(5)P Regulates Autophagosome Biogenesis (2015, background): “…Vicinanza, Viktor I. Korolchuk, ..., Jonathan H. Clarke, David C. Rubinsztein Correspondence dcr1000@cam.ac.uk In Brief PI(3)P, the product of VPS34, regulates canonical autophagy; however, mammalian cells can produce autophagosomes through enigmatic noncanonical VPS34-independent pathways.”
Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies (2024, background): “229 However, the abundant accumulation of autophagic vacuoles in swollen (malnourished) neurons is observed to have a linkage with A β / APP-β CTF, suggesting that autophagy clearance is severely disrupted under pathological conditions and is closely linked to amyloid pathology.”
Compromised MAPK signaling in human diseases: an update (2015, background): “Stimulation of autophagy, a major degradation pathway for such aggregates, has thus been considered a potential therapeutic strategy for these diseases (Ghavami et al. 2014; Nixon 2013; Sarkar and Rubinsztein 2008).”