The protein structures that shape caspase activity, specificity, activation and inhibition.

By P. Fuentes-Prior, G. Salvesen. Biochemical Journal, 2004

890 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ece4139ce0d026c325c243285bba5489696b2811

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. L. Galluzzi
2. Guido Kroemer
3. S. Riedl
4. Sharad Kumar
5. J. Tschopp
6. W. Zong
7. Craig B. Thompson
8. G. Salvesen

In Epidemiology

1. Guido Kroemer
2. L. Galluzzi
3. J. Tschopp
4. Sharad Kumar
5. Annick Mayor
6. C. Brenner
7. Fabio Martinon
8. S. Riedl

In Molecular Biology

1. Guido Kroemer
2. J. Tschopp
3. T. Kanneganti
4. L. Galluzzi
5. Fabio Martinon
6. G. Salvesen
7. Annick Mayor
8. Craig B. Thompson

Citations in the corpus

• Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family (2006, background): “There are 11 human caspases, and those that have a clear role in apoptosis can be divided into those involved in the initiation (caspase-2, caspase-8, caspase-9 and caspase-10) or the execution (caspase-3, caspase-6 and caspase-7) phase of apoptosis (Fuentes-Prior & Salvesen, 2004).”
• Cell death in the nervous system (2006, result): “Contrary to earlier models, cleavage of initiator caspases is neither required nor sufficient for activatio”
• Caspase function in programmed cell death (2007, background): “It is activated following cleavage by caspase-8 or -9, but not by caspase-2.(8,9,124)”
• Necrotic death as a cell fate. (2006, background): “The third class includes inflammatory caspases (1, 4, 5, 11, 12, and possibly 14; 11/12 are murine equivalents of human 4/5) (Fuentes-Prior and Salvesen 2004).”
• Mitochondrial membrane permeabilization in cell death. (2007, background): “However, not all caspases are required for apoptosis and the process generally results from the activation of a limited subset of caspases, in particular, caspases-3, -6, and -7 (231).”
• The inflammasomes: guardians of the body. (2009, background): “death-inducing signaling complex (DISC) for caspase-8 and -10, the PIDDosome for caspase2, and the apoptosome for caspase-9 (73).”
• The apoptosome: signalling platform of cell death (2007, background): “A complete overview of the catalytic details of caspases can be found elsewher”
• Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “Several clinical trials have been done to target the cellintrinsic caspase-inhibiting mechanisms, including both BCL-2 family members and cIAPs, to therapeutically activate caspase function in cancer cells (54, 196).”