Lipid Droplet Biogenesis
By T. Walther, Jeeyun Chung, Robert V Farese. Current Opinion in Cell Biology, 2014
1,009 citations recorded by the source corpus.
Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane. Additionally, large LDs can form either by growth of existing LDs or by the combination of smaller LDs through several distinct mechanisms. Here, we review recent insights into the molecular process governing LD biogenesis and highlight areas of incomplete knowledge.
Subfields: Biochemistry, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/3923321f08109675b746aa1d20ff96ffda455fcd
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Citations in the corpus
- Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “Importantly, there is a strong requirement for DGAT1, one of two enzymes catalyzing the final and only dedicated reaction in TAG synthesis, which is required for droplet biogenesis from the endoplasmic reticulum (Wilfling et al., 2014).”
- Triglyceride metabolism in the liver (2017, neutral): “Indicative of its role in LD biogenesis, CCT is recruited from the cytosol to expanding LDs in a variety of cell types to provide PC for LD surface expansion (278).”
- Lipolysis: cellular mechanisms for lipid mobilization from fat stores (2021, background): “Putative DDHD2-dependent mechanisms that may underlie hereditary spastic paraplegia include (1) the accrual of LDs, which would hinder protein and/or lipid trafficking required for synapse assembly276, (2) reduced cardiolipin biosynthesis and increased ROS production in mitochondria, which would tri”