Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection.

By J. Linden. Annual Review of Pharmacology and Toxicology, 2001

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Adenosine receptors: therapeutic aspects for inflammatory and immune diseases (2006, background): “Adenosine accumulates in the extracellular space in response to metabolic stress and cell damage ( Box 1 ), and elevations in extracellular adenosine are found in conditions of ischaemia, hypoxia, inflammation and traum”
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. (2001, neutral): “These receptors are probably located at the terminals of the striatopallidal GABAergic neurons (Rosin et al., 1998; Svenningsson et al., 1999b; Linden, 2001).”
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage (2001, neutral): “, including cell-surface adenosine purinergic receptor”
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. (2002, background): “Adenosine is a critical mediator during ischemia and hypoxia (9).”