Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
By G. Haskó, J. Linden, B. Cronstein, P. Pacher. Nature reviews. Drug discovery, 2006
1,247 citations recorded by the source corpus.
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development and progression of disease. This recent heightened awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.
Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/f589174d725445dd62fb9482d7eaddb5a08caac9
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Citations in the corpus
- Immune cell regulation by autocrine purinergic signalling (2011, background): “Compared to the P2 receptors, a much wider selection of powerful and specific drugs is available for the modulation of adenosine receptor”
- Immunity, inflammation and cancer: a leading role for adenosine (2013, neutral): “APCP, adenosine 5ʹ-(α,β-methylene) diphosphate; ARL67156, 6-N,N-diethyl-D-β,γ dibromomethylene A TP; Cl-IB-MECA, 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofu ranuronamide; CTLA4, cytotoxic T lymphocyte-associated antigen 4; IB-MECA,1-deoxy-1-[6-[[(3-iodopheny”