Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.

By Kristin Synnestvedt, G. Furuta, Katrina M. Comerford, N. Louis, Jörn Karhausen, H. Eltzschig, K. R. Hansen, L. Thompson, S. Colgan. Journal of Clinical Investigation, 2002

797 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Physiology

View Paper: https://www.semanticscholar.org/paper/16b8fcfd68440f8fb5f5e1270c166f84600aa177

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. N. Prabhakar
2. M. Schwartz
3. G. Semenza
4. C. V. Dang
5. Navdeep S. Chandel
6. P. Vaupel
7. J. Pouysségur
8. M. C. Simon

In Physiology

1. P. Pacher
2. Luca Antonioli
3. E. Vizi
4. Steffen Jung
5. G. Haskó
6. G. Semenza

Citations in the corpus

• Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus (2013, positive): “5mg) daily for a period of 7–14 days with a,b-methylene ADP (APCP; Sigma), a CD73 inhibitor (Synnestvedt et al., 2002).”
• ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “CD73 expression is induced under hypoxic conditions as a result of HIF-1-dependent transcriptional activation of the Nt5e gene (321).”
• CD39 and CD73 in immunity and inflammation (2013, positive): “Early studies, based on both genetic knockout models and pharmacological inhibition of CD39 and CD73 in mice, showed that these enzymes are crucial for protecting against increased vascular permeability and neutrophil extravasation during local hypoxia [32,34,59].”