Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation

By A. Migliaccio, G. Castoria, M. Domenico, A. de Falco, A. Bilancio, M. Lombardi, M. Barone, Donatella Ametrano, M. Zannini, C. Abbondanza and 1 more. EMBO Journal, 2000

690 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/ec39f907610f723c6c917e09810ea647071c0533

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. Noble
2. E. Levin

In Genetics

1. S. Manolagas
2. Stephen Honig
3. P. Rackoff

In Pulmonary and Respiratory Medicine

1. P. Noble
2. E. Levin

Citations in the corpus

• Sex steroids and bone. (2002, background): “The Src kinase physically associates with the ER or AR proteins (Migliaccio et al., 2000).”
• CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “…kinase family, c-Src (Src), may physically associate with the intracytoplasmic domain of CD44 (Taher et al., 1996; Bourguignon et al., 2001), leading to downstream ERK phosphorylation via a Ras-Raf-MEK-dependent pathway (Ishida et al., 1998; Migliaccio et al., 2000; Mahabeleshwar and Kundu, 2003).”
• Integration of the extranuclear and nuclear actions of estrogen. (2005, background): “Important nonreceptor tyrosine kinases such as Src are also involved as intermediary steps (34).”
• Androgen receptor in prostate cancer. (2004, background): “The tyrosine kinase activity of Src is normally autoinhibited by interaction between the tyrosine kinase domain and the Src homology 2 (SH2) and SH3 domains.”
• Molecular genetics of prostate cancer: new prospects for old challenges. (2010, background): “In particular , stimulation of AR signaling leads to activation of SRC in prostate cancer cells, which can lead to phosphorylation of AR, castration resistance, and cellular proliferation and invasiveness (Migliaccio et al. 2000; Agoulnik et al. 2005; Kraus et al. 2006).”