Transduction of mechanical and cytoskeletal cues by YAP and TAZ

By G. Halder, S. Dupont, S. Piccolo. Nature reviews. Molecular cell biology, 2012

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How researchers see this paper

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Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “their cytoskeleton tension, generating internal forces that are transmitted to the environment by adhesion sites [72].”
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. (2013, positive): “Mechanical forces are ideally suited to serve as messenger of this global control, as it has been recently shown that forces display long-range and broad-scale effects (Halder et al., 2012; Guo et al., 2012).”
YAP/TAZ at the roots of cancer (2016, background): “…these features are intimately connected to the cell’s location within the 3D architecture of tissues, including the attachment to other cells and to the surrounding extracellular matrix (ECM), and influenced by the chemical and physical features of cell’s microenvironement (Halder et al., 2012).”