Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells.

By K. Vattem, R. Wek. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,732 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ebc0a0b38c9cddb95ea9199885a0b343b205fc7e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Kaufman
2. D. Ron
3. Afshin Samali
4. A. Gorman
5. H. Harding
6. Peter Walter
7. Nahum Sonenberg
8. G. Hotamışlıgil

Citations in the corpus

• THE MECHANISM OF EUKARYOTIC TRANSLATION INITIATION AND PRINCIPLES OF ITS REGULATION (2010, background): “The best-characterized mammalian examples are the transcription factors ATF4 and ATF5, the expression of which is increased ∼ 5-fold by activation of PER”
• Regulation of translation via mRNA structure in prokaryotes and eukaryotes. (2005, background): “Recent evidence suggests that translation of the ATF4 transcription factor in mammals is regulated via a GCN4like mechanism (Vattem and Wek, 2004).”
• Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “those conventionally used to induce L-LTP (Cracco et al., 2005; Vickers et al., 2005).”
• The role for endoplasmic reticulum stress in diabetes mellitus. (2008, background): “During ER stress, however, the presence of high levels of eIF2 phosphorylation delays the capacitation of scanning ribosomes, favoring reinitiation at the ATF4 initiation codon and resulting in increased ATF4 translation (88, 89).”
• Endoplasmic Reticulum Stress in Liver Disease (2010, positive): “Upon eIF2a phosphorylation, ribosomes scan through the upstream uORFs to initiate Atf4 translation [136].”
• Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response (2004, background): “Furthermore, while this manuscript was under preparation, Vattem and Wek (2004) reported that a point mutation abolishing uORF1 does not significantly de-repress the ATF4-luciferase reporter used in our earlier work and has a markedly negative effect on ATF4-luciferase inducibility by pharmacologi”
• Oxidative stress response and Nrf2 signaling in aging. (2015, positive): “In addition, ATF4 expression is also regulated at the translational level through the change of phosphorylation of eIF2α, which binds to the 5′- untranslated region of the ATF4 mRNA [342, 343].”
• Nutrient sensing and TOR signaling in yeast and mammals (2017, neutral): “The uORF containing mRNA encodes a basic leucine zipper transcription factor termed ATF4 (activating transcription factor 4) in mammals (Harding et al , 2000; Vattem & Wek, 2004) and Gcn4 in yeast (Hinnebusch, 1984).”
• Translational regulation of gene expression during conditions of cell stress. (2010, background): “The presence of uORFs in, for example, ATF4, is responsible for this increase in expression under stress conditions, and it is becoming clear that a similar mechanism is likely to be more widely utilized by stress response genes (Vattem and Wek, 2004).”