The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention.

By A. Sheldon, M. Robinson. Neurochemistry International, 2007

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Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified (2013, background): “Excess of Glu leads to neuronal cell death and Glu has an important role in the pathophysiology of some neuropsychiatric disorders [70].”
Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence? (2015, background): “…HYPOTHESIS OF CHRONIC GLUTAMATE TOXICITY IN NEURODEGENERATION As EAATs have been found to be down-regulated in many diseases of the nervous system (Sheldon and Robinson, 2007) Frontiers in Neuroscience | www.frontiersin.org 12 December 2015 | Volume 9 | Article 469 and hypothetically increased…”
Glutamate as a neurotransmitter in the healthy brain (2014, background): “Considering the importance of the glutamate transporters, pharmacological manipulation of transporter function may prove to be highly interesting from a therapeutic point of view (Sheldon and Robinson 2007).”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “The deleterious excitotoxic side effects of increased system xc - activity might be amplified in many diseases of the CNS as down-regulation of EAATs, which, usually balance system xc - mediated glutamate release, is commonly observed [for review see (247)] (Fig.”