The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity1

By C. Addison, T. Daniel, M. Burdick, Hua Liu, J. Ehlert, Y. Xue, Linda Buechi, A. Walz, A. Richmond, R. Strieter. Journal of Immunology, 2000

625 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/ebb1f446d506f928bb9d05034d71d1ab507eaf36

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In Immunology

1. B. K. Pedersen
2. M. Febbraio
3. C. Fischer

In Oncology

1. B. K. Pedersen
2. M. Febbraio

Citations in the corpus

• Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases (2017, positive): “In endothelial cells, CXCR1 and/or CXCR2 knockdown with shRNAs showed that both receptors were critical for CXCL8-mediated endothelial cell proliferation, survival, migration, invasion, tube formation and angiogenesis, which corroborates previous studies performed with antibodies against CXCR1/2 and”
• CXC chemokines in angiogenesis (2000, background): “ELR+ CXC chemokinemediated angiogenesis was inhibited in CXCR2 / mice, and in the presence of neutralizing antibodies to CXCR2 in other animal models of angiogenesis [26].”
• Muscle as an endocrine organ: focus on muscle-derived interleukin-6. (2008, background): “The IL-8 produced by the exercising limb might elicit its response by interacting with the CXCR2 receptor present in the endothelia of capillaries (3, 133).”
• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “Both CXCR1 and CXCR2 may be expressed by endothelial cells and mediate angiogenesis (Li et al., 2005); however, CXCR2 is considered to be more important in vivo (Addison et al., 2000; Li et al., 2005; Keeley et al., 2010).”
• The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. (2005, background): “In total, these data strongly support a role for CXCR2 in angiogenesis induced by ELF+ chemokines (Addison et al., 2000).”
• IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis1 (2003, background): “It has been shown recently that CXCR2 is the putative receptor involved in mediating ELR CXC chemokine-mediated angiogenic activity (31), which has, however, not been shown conclusively.”
• Role of myokines in exercise and metabolism. (2007, background): “The IL-8 produced by the exercising limb might elicit its response by interacting with the CXCR2 receptor present in the endothelia of capillaries (1, 28).”