Autophagy at the crossroads of catabolism and anabolism

By Jasvinder Kaur, Jayanta Debnath. Nature reviews. Molecular cell biology, 2015

937 citations recorded by the source corpus.

Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome. Starvation-induced protein degradation is a salient feature of autophagy but recent progress has illuminated how autophagy, during both starvation and nutrient-replete conditions, can mobilize diverse cellular energy and nutrient stores such as lipids, carbohydrates and iron. Processes such as lipophagy, glycophagy and ferritinophagy enable cells to salvage key metabolites to sustain and facilitate core anabolic functions. Here, we discuss the established and emerging roles of autophagy in fuelling biosynthetic capacity and in promoting metabolic and nutrient homeostasis.

Subfields: Biochemistry, Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/eb92d37e24fff298990c71b59f04f49c14c8c368

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Citations in the corpus

Molecular definitions of autophagy and related processes (2017, neutral): “…nutritional, metabolic, chemical, physical, and hormonal cues can alter (increase or decrease) the ability of microautophagy, CMA, and macroautophagy to degrade autophagy substrates (Galluzzi et al , 2014; Green & Levine, 2014; Kaur & Debnath, 2015; Mukherjee et al , 2016; Tasset & Cuervo, 2016).”
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Autophagy is the process by which organelles and cytosolic macromolecules are engulfed by membranes to form autophagosomes in which the engulfed materials are transported to the lysosome for digestion and recycling.(109)”
Targeting autophagy in cancer (2018, background): “Another way autophagy is categorized is into nonselective and selective autophagy.(9) On one hand, nonselective autophagy occurs when cells degrade their cytoplasm in a bulk manner.”
A systems study reveals concurrent activation of AMPK and mTOR by amino acids (2016, background): “Secondly, the upregulation of biosynthetic processes requires increased amounts of metabolite intermediates, which are provided by autophagy as well 16 .”
Autophagy and Mitophagy in Cardiovascular Disease. (2017, background): “Besides proceeding at baseline levels in physiological conditions, autophagy responds to a wide variety of microenvironmental triggers, including nutritional, metabolic, hormonal, physical, chemical, and biological cues.(5,6) In the vast majority of these settings, autophagic responses promote adapt”