Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

By Jing L Guo, V. Lee. Nature Medicine, 2014

606 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “It has been reported that senes cent and inflammatory cells (astrocytes) are present in the brain of PD patients (23) and a “transmission hypothesis” has been pro posed regarding the pathogenesis of “PD as a prion disease” (161) where intercellular transmission of pathological protein aggregates (α-”
A designer AAV variant permits efficient retrograde access to projection neurons (2016, background): “Projection neurons have also been impli- 372 Neuron 92, 372–382, October 19, 2016 ª 2016 Elsevier Inc. cated in the spread of several neurodegenerative diseases from spatially localized sites of onset (Guo and Lee, 2014; Seeley et al., 2009).”
Distinct tau prion strains propagate in cells and mice and define different tauopathies (2014, background): “Recently, however, experimental work on diverse amyloids has generated new interest (Frost and Diamond, 2010; Guo and Lee, 2014).”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “In addition to the transmission of pathogenic proteins, EV secretion is a primary method of internal communication between neurons in neurodegenerative diseases [122].”